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KMID : 1007520070160040632
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Food Science and Biotechnology
2007 Volume.16 No. 4 p.632 ~ p.635
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Neuroprotective Effect of Scopoletin from Angelica dahurica on Oxygen and Glucose Deprivation-exposed Rat Organotypic Hippocampal Slice Culture
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Son Dong-Wook
Lee Pyeong-Jae
Lee Jong-Seok
Lee Sang-Hyun
Choi Sang-Yoon
Lee Jong-Won
Kim Sun-Yeou
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Abstract
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This study examined the neuroprotective effect of scopoletin from Angelica dahurica against oxygen and glucose deprivation-induced neurotoxicity in a rat organotypic hippocampal slice culture. Scopoletin reduced the propidium iodide (PI) uptake, which is an indication of impaired cell membrane integrity. In addition, it inhibited the loss of NeuN, which represents the viability of neuronal cells. The results suggests that scopoletin from A. dahurica protects neuronal cells from the damage caused by oxygen and glucose deprivation.
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KEYWORD
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Angelica dahurica, scopoletin, oxygen-glucose deprivation, hippocampus slice culture, neuroprotection
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